Mild irritation and dryness is possible whenever starting a new treatment. This is typically a temporary reaction that will often subside after about 4 weeks of use as your skin gets used to the products. For those with sensitive skin, it may be best to apply once daily at the beginning, and then increase to twice daily over time as tolerated. If needed, try a gentle, non-comedogenic moisturizer to help manage irritation. Always best to consult your physician or healthcare provider if you are unsure and discontinue use if you experience any significant irritation.