We are proud to say that none of our clinical trial participants experienced any significant side effects from using the products over the course of our trial. In addition, we elected to put our products through a rigorous testing process called repeat insult patch testing (RIPT), which is the gold standard in testing skin irritation from skin care products. All of our products passed and no significant irritation was found. Individual results may vary. Always best to consult your physician if you are unsure and discontinue use if you experience any side effects.